David Archer, PhD, Scientific Director
David R. Archer, PhD, is an Associate Professor in the Department of Pediatrics of Emory University School of Medicine. Dr. Archer serves as the Scientific Director of the Pediatric Animal Physiology Core.
Dr. Archer's research interests are focused on the pathogenesis of sickle cell disease with respect to the generation, prevention, and treatment of organ dysfunction. His lab's studies on the pathogenesis of sickle cell nephropathy are likely to examine the role of endothelial cells in the generation of both proteinuria and the concentrating defects associated with renal dysfunction. His lab employs hematopoietic stem cell transplantation to correct the hematological defect in murine models of sickle cell disease.
His lab has considerable experience in the maintenance of sickle mouse colonies, transplantation, and hematological and functional analysis of the outcomes. In their collaborative projects, these skills enable them to generate the sickle phenotype in the models of oxidant stress included in this project and therefore allow them to investigate the role of various oxidant response genes in the pathogenesis of sickle vasculopathy.
Ming Shen, Technical Director
With over 20 years of research experience at Emory University, Ming has worked in molecular biology, cellular biology, and immunology. Her most passionate area of interest is animal survival surgeries with expertise in:
- Aortic Banding
- Bile duct ligation
- Bone Marrow Transplant
- Carotid Artery ligation
- Coronary ligation
- Femoral Artery ligation
- Liver ischemia/reperfusion
- Nephrectomy, 5/6
- Pulmonary Banding
- Tail vein injections
Ming also works with animal bio-imaging including rodent High-Frequency Ultrasound Imaging and Photoacoustic Imaging (Vevo3100 & LAZR), and ECHO Guide in-vivo stem cell injections in post Pulmonary banding surgery rat’s right ventricular.