Faculty Directory

David Archer, PhD

David Archer, PhD headshot

Director of Pediatric Flow Cytometry Service
Director of Basic Research for Sickle Cell Program
Aflac Cancer & Blood Disorders Center
Associate Professor of Pediatrics,
Emory University School of Medicine

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My research interests are focused on the pathogenesis of sickle cell disease in respect to the generation, prevention and treatment of organ dysfunction. Our studies on the pathogenesis of sickle cell nephropathy are likely to examine the role of endothelial cells in the generation of both the proteinuria and the concentrating defects associated with renal dysfunction. In particular my lab employs hematopoietic stem cell transplantation to correct the hematological defect in murine models of sickle cell disease. We have considerable experience in the maintenance of sickle mouse colonies, transplantation, hematological and functional analysis of the outcomes. In our collaborative projects, these skills will enable us to generate the sickle phenotype in the models of oxidant stress included in this project and therefore allow us to investigate the role of various oxidant response genes in the pathogenesis of sickle vasculopathy.

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