Publications and Grants

The Aflac Cancer and Blood Disorders Center of Children's Healthcare of Atlanta and Emory University School of Medicine provides advanced clinical care, innovative treatment and research options for children and young adults. We are one of the largest pediatric cancer, hematology, blood and marrow transplant (BMT) programs in the country. In 2017, our faculty published more than 130 peer-reviewed publications highlighting innovative research findings and discoveries. We are grateful for the collaborative relationships we have with other pediatric hematologists and oncologists nationwide. 

2018

Aguilera D, Castellino RC, Janss A, Schniederjan M, McNall R, MacDonald T, Mazewski C. Clinical responses of patients with diffuse leptomeningeal glioneuronal tumors to chemotherapy. Childs Nerv Syst. 2018 Feb;34(2):329-334. doi: 10.1007/s00381-017-3584-x. Epub 2017 Sep 30. PMID:28965234

Akinsola B, Hagbom R, Zmitrovich A, Kavanagh PL, Ashkouti A, Simon HK, Fleming A, Jain S, Dampier C, Morris CR. (2018) Impact of Intranasal Fentanyl in Nurse Initiated Protocols for Sickle Cell Vaso-occlusive Pain Episodes in a Pediatric Emergency Department. Amer J Hematol 2018 May 17. doi: 10.1002/ajh.25144. [Epub ahead of print]

Branchford BR, Stalker TJ, Law L, Acevedo G, Sather S, Brzezinski C, Wilson KM, Minson K, Lee-Sherick AB, Davizon-Castillo P, Ng C, Zhang W, Neeves KB, Lentz SR, Wang X, Frye SV, Earp SH 3rd, DeRyckere D, Brass LF, Graham DK, Di Paola JA.  The small-molecule MERTK inhibitor UNC2025 decreases platelet activation and prevents thrombosis.  J Thromb Haemost. 2018 Feb;16(2):352-363. doi: 10.1111/jth.13875. Epub 2018 Jan 12. PMID: 29045015

Brinkman TM, Recklitis CJ, Michel G, Grootenhuis MA, Klosky JL. Psychological symptoms, social outcomes, socioeconomic attainment, and health behaviors among survivors of childhood cancer: Current state of the literature. Journal of Clinical Oncology, In Press.

Brockman JM, Blanchard AT, Pui-Yan V Ma, Derricotte WD, Zhang Y, Fay ME, Lam WA, Evangelista FA, Mattheyses AL, Salaita K. “Mapping the 3D orientation of piconewton integrin traction forces.” Nature Methods. 2018 Feb;15(2):115-118

Carlos EC, Ajay D, Muniz-Alers S, Wechsler DS, Sushama DV, Rice HE, Madden J, Routh JC. Wilms Tumor after Orthotopic Liver Transplant in a Patient with Alagille Syndrome. Urology, 2018 (in press)

Chinnadurai R, Rajan D, Qayed M, Arafat D, Garcia M, Liu Y, Kugathasan S, Anderson LJ, Gibson G, Galipeau J. Potency Analysis of Mesenchymal Stromal Cells Using a Combinatorial Assay Matrix Approach. Cell Rep. 2018 Feb 27;22(9):2504-2517. doi: 10.1016/j.celrep.2018.02.013. PubMed PMID: 29490284; PubMed Central PMCID: PMC5855117.

Chonat S, McLemore M, Bunting S, et al. Congenital Dyserythropoietic Anemia Type I diagnosed in a young adult with history of splenectomy in childhood for presumed hemolytic anemia. British J Haematol. 2018 Apr 20. doi: 10.1111/bjh.15217. [Epub ahead of print]

Chonat S, Quarmyne M, Bennett CM, Dean CL, Joiner CH, Fasano RM, and Stowell SR. Contribution of Alternative Complement Pathway to Delayed Hemolytic Transfusion Reaction in Sickle Cell Disease. Haematologica. 2018 May 24. doi: 10.3324/haematol.2018.194670. [Epub ahead of print]

Chow EJ, Chen Y, Hudson MM, Feijen EAM, Kremer LC, Border WL, Green DM, Meacham LR, Mulrooney DA, Ness KK, Oeffinger KC, Ronckers CM, Sklar CA, Stovall M, van der Pal HJ, van Dijk IWEM, van Leeuwen FE, Weather RE, Robison LL, Armstrong GT and Yasui Y. Prediction of ischemic heart disease and stroke among childhood cancer survivors. J Clin Oncol. 2018 Jan 1;36(1):44-52. doi: 10.1200/JCO.2017.74.8673. Epub 2017 Nov 2. PMID: 29095680

Coccia PF, Pappo AS, Beaupin L, Borges VF, Borinstein SC, Chugh R, Dinner S, Folbrecht J, Frazier AL, Goldsby R, Gubin A, Hayashi R, Huang MS, Link MP, Livingston JA, Matloub Y, Millard F, Oeffinger KC, Puccetti D, Reed D, Robinson S, Rosenberg AR, Sanft T, Spraker-Perlman HL, von Mehren M, Wechsler DS, Whelan KF, Yeager N, Gurski LA, Shead DA. Adolescent and Young Adult Oncology, Version 2.2018, NCCN Clinical Practice Guidelines in Oncology. J Natl Compr Canc Netw 16(1):66-97, 2018. PMID: 29295883

Compernolle V, Chou ST, Tanael S, Savage W, Howard J, Josephson CD, Odame I, Hogan C, Denomme G, Shehata N; International Collaboration for Transfusion Medicine Guidelines.  Red blood cell specifications for patients with hemoglobinopathies: a systematic review and guideline.  Transfusion 2018 Apr 26. doi: 10.1111/trf.14611. [Epub ahead of print] Review  PMID: 29697146

Cook AA, Deng W, Ren J, Li R, Sondek J, Bergmeier W. Calcium-induced structural rearrangements release autoinhibition in the Rap-GEF, CalDAG-GEFI. Journal of Biological Chemistry. 2018:jbc. RA118. 002712

Crandall W, Davis JT, Dotson J, Elmaraghy C, Fetzer M, Hayes, Jr. D, Horwitz EM, Kogon A, Olshefski R, Patel H, Brilli R. Clinical Indices can Standardize and Monitor Pediatric Care: A novel mechanism to Improve Quality and Safety. Journal of Pediatrics, 193:190-195.e1, 2018.  PMID: 29212624

Das R, Bar N, Ferreira M, Newman AM, Zhang L, Bailur JK, Bacchiocchi A, Kluger H, Wei W, Halaban R, Sznol M, Dhodapkar MV, Dhodapkar KM. Early B cell changes predict autoimmunity following combination immune checkpoint blockade. J Clin Invest. 2018 Feb 1;128(2):715-720. PMID: 29309048.

Deng W, Voos KM, Li R. A new redox switch regulating von Willebrand factor activity. Journal of thrombosis and haemostasis. JTH. 2018. 10.1111/jth.14147.

Dixon SB, Bjornard KL, Alberts NM, Armstrong GT, Brinkman TM, Chemaitilly W, Ehrhardt MJ, Fernandez-Pineda I, Force L, Gibson TM, Green DM, Howell C, Kaste SC, Kirchhoff A, Klosky JL, Krull KR, Lucas J, Mulrooney DA, Ness KK, Wilson CL, Yasui Y, Robison LL, Hudson MM. Factors influencing risk-based care of the childhood cancer survivor in the 21st century. CA: A Cancer Journal for Clinicians, In Press.

Eaton, C.K., Gutierrez-Colina, A.M., Quast, L.F., Liverman, R., Lee, J.L., Mee, L.M.,…& Blount, R.L. (in press). Multimethod assessment of nonadherence in adolescents and young adults with solid organ transplants. Journal of Pediatric Psychology. Advance Online Access. doi: 10.1093/jpepsy/jsy016 

Fernandez-Pineda I, Davidoff AM, Lu L, Rao BN, Wilson CL, Srivastava DK, Klosky JL, Metzger ML, Krasin MJ, Ness KK, Pui CH, Robison LL, Hudson MM, Sklar CA, Green DM, Chemaitilly W. Impact of ovarian transposition before pelvic irradiation on ovarian function among long-term survivors of childhood hodgkin lymphoma: A report from the St. Jude Lifetime Cohort Study. Pediatric Blood & Cancer, In Press.

Fish A, Rollins MR, Langley P, King M, Forney C, Josephson CD, Fasano RM.  Twiddler's syndrome in an adolescent female with an apheresis port. Transfusion. 2018 Feb;58(2):280-281. doi: 10.1111/trf.14242.  PMID:  29411399

Frazier AL, Stoneham S, Rodriguez-Galindo C, Dang H, Xia C, Olson TA, Murray MJ, Amatruda JF, Shaikh F, Pashankar F, Billmire D, Krailo M, Stark D, Brougham MFH, Nicholson JC, Hale JP. Comparison of Carboplatin vs Cisplatin in the Treatment of Pediatric Extracranial Malignant Germ Cell Tumors: A Report of the Malignant Germ Cell International Consortium. Eur J Cancer (in press)

Garcia TB, Fosmire SP, Porter CC. Increased activity of both CDK1 and CDK2 is necessary for the combinatorial activity of WEE1 inhibition and cytarabine. Leuk Res. 2018 Jan;64:30-33. doi: 10.1016/j.leukres.2017.11.004. Epub 2017 Nov 11. PMID: 29175378

Garfall AL, Stadtmauer EA, Hwang WT, Lacey SF, Melenhorst JJ, Krevvata M, Carroll MP, Matsui WH, Wang Q, Dhodapkar MV, Dhodapkar KM, Das R, Vogl DT, Weiss BM, Cohen AD, Mangan PA, Ayers EC, Nunez-Cruz S, Kulikovskaya I, Davis MM, Lamontagne A, Dengel K, Kerr ND, Young RM, Siegel DL, Levine BL, Milone MC, Maus MV, June CH. Anti-CD19 CAR T cells with high-dose melphalan and autologous stem cell transplantation for refractory multiple myeloma. JCI Insight. 2018 Apr 19;3(8). pii: 120505. doi: 10.1172/jci.insight.120505. PMID:29669947.

Gilleland Marchak J, Seidel KD, Mertens AC, Ritenour CWM, Wasilewski-Masker K, Leisenring WM, Sklar CA, Ford JS, Krull KR, Stovall M, Robison LL, Armstrong GT, Meacham LR.Perceptions of risk of infertility among male survivors of childhood cancer: A report from the Childhood Cancer Survivor Study.Cancer. 2018 Apr 17. doi: 10.1002/cncr.31343. [Epub ahead of print] PMID: 29663341]

Goldstein-Leever A, Cohen LL, Dampier C, Sil S. (2018). Parent pain catastrophizing predicts child depressive symptoms in youth with sickle cell disease. Pediatric Blood and Cancer, 65 (7), e27027.

Grace RF, ….. Chonat S et al. The Clinical Spectrum of Pyruvate Kinase Deficiency:  Data from the Pyruvate Kinase Deficiency Natural History Study. Blood. 2018 Mar 16. pii: blood-2017-10-810796. [Epub ahead of print]

Gu L, Zhang H, Liu T, Draganov A, Yi S, Wang B, Zhou M. Inhibition of MDM2 by a rhein-derived compound AQ-101 supresses cancer development in SCID mice. Mol Cancer Ther. 2018;17:497-507.

Gutiérrez OM*, Irvin MR*, Chaudhary NS, Cushman M, Zakai NA, David VA, Limou S, Pamir N, Reiner AP, Naik RP, Sale MM, Safford MM, Hyacinth HI, Judd SE, Kopp JB, Winkler CA. APOL1 nephropathy risk variants and incident cardiovascular disease events in community-dwelling Black adults. Circulation: Genomic and Precision Medicine. 2018 – Epub Ahead of Print

Healey, J.F, Parker, E.T., Lollar P. Identification of Aggregates in Therapeutic Formulations of Recombinant Full-Length Factor VIII Products by Sedimentation Velocity Analytical Ultracentrifugation. 2018 J Thromb Haemost. 16,303-315.

Heath JL, Aumann WK, Maxfield CM, Wechsler DS. Isolated Central Nervous System Chloroma as a Presenting Sign of Relapsed Pediatric Acute Lymphoblastic Leukemia. J Pediatr Hematol Oncol. 2018 Jan 12. doi: 10.1097/MPH.0000000000001085. [Epub ahead of print].

Hosoba S, Waller EK, Shenvi N, Graiser M, Easley KA, Al-Kadhimi Z, Andoh A, Antun AG, Barclay S, Josephson CD, Koff JL, Khoury HJ, Langston AA, Zimring JC, Roback JD, Giver CR.  Peritransplantation Red Blood Cell Transfusion Is Associated with Increased Risk of Graft-versus-Host Disease after Allogeneic Hematopoietic Stem Cell Transplantation.  Biol Blood Marrow Transplant. 2018 Jan 4. pii: S1083-8791(18)30003-X. doi: 10.1016/j.bbmt.2018.01.003. [Epub ahead of print]  PMID:  29307717.l

Huang IC, Bhakta N, Brinkman TM, Klosky JL, Krull KR, Srivastava DK, Hudson MM, Robison LL. Determinants and effects of financial hardship among long-term adult survivors of childhood cancer: A report from the St. Jude Lifetime Cohort Study. Journal of the National Cancer Institute, In Press.

Huang IC, Klosky JL, Young CM, Murphy SE, Krull KR, Srivastava DK, Hudson MM, Robison LL. Misclassification of self-reported smoking and determinants in childhood cancer survivors: Results from the St. Jude Lifetime Cohort Study. Pediatric Blood & Cancer, In Press.

Hyacinth HI, Carty CL, Seals RS, Irvin MR, Naik RP, Burke GL, Zakai NA, Wilson JG, Franceschini N, Winkler CA, David VA, Kopp J, Judd SE, Adams RJ, Longstreth Jr. WT, Egede L, Lackland DT, Taylor H, Manson JE, Howard V, Allison M, Gee BE, Correa A, Safford MM, Arnett DK, Howard G, Reiner AP, Cushman M. Sickle Cell Trait and Ischemic Stroke in African Americans. JAMA: Neurology. 2018 Apr; Epub Ahead of Print

Hyacinth, Hyacinth I., and Robert J. Adams. Sickle cell disease and other hemoglobinopathies. In Uncommon Causes of Stroke. Kaplan L, Biller, J (eds). Oxford University Press, 2018.
Islam M, Mezencev R, McFarland B, Brink H, Campbell B, Tasadduq B, Waller EK, Lam W, Alexeev A, Sulchek T. “Microfluidic cell sorting by stiffness to examine heterogenic responses of cancer cells to chemotherapy.” Cell Death Dis. 2018 Feb 14;9(2):239

Jayaram DT, Pustulka SM, Mannino RG, Lam WA, Payne CK. “Protein Corona in Response to Flow: Effect on Protein Concentration and Structure.” Biophys J. 2018 Apr 9

Jenny L, Dobó J, Gál P, Pál G, Lam WA, Schroeder V. “MASP-1 of the complement system enhances clot formation in a microvascular whole blood flow model.” PLoS One. 2018 Jan 11;13(1):e0191292.

Jin L, Chun J, Pan C, Kumar A, Zhang G, Ha Y, Li D, Alesi GN, Kang Y, Zhou L, Yu WM  ar Salary Statistics- CPerry , K. R. Magliocca, F. R. Khuri, C. K. Qu, C. Metallo, T. K. Owonikoko, and S. Kang. The PLAG1-GDH1 axis promotes anoikis resistance and tumor metastasis through CamKK2-AMPK signaling in LKB1-deficient lung cancer. Molecular Cell. 2018; 69:87-99

Kanter, J, Heath, LE, Knorr, J, Agbenyega, ET, Colombatti, R, Dampier, C,  Hassab, H, Manwani, D, Robitaille, N, Brown, PB, Jakubowski, JA, Yao, S, Hoppe, C (2018) Novel findings from The Multinational DOVE study on geographic and age-related differences in pain perception and analgesic usage in children with sickle cell anaemia, Br J Haematol. 2018 Apr 20. doi: 10.1111/bjh.15250. [Epub ahead of print]

Keller FG, Castellino SM, Chen L, Pei Q, Voss SD, McCarten KM, Senn SL, Buxton AB, Bush R, Constine LS, Schwartz CL. Results of the AHOD0431 trial of response adapted therapy and a salvage strategy for limited stage, classical Hodgkin lymphoma: A report from the Children's Oncology Group. Cancer. 2018 May 8. PMID: 29738613

Klosky JL, Lehmann V, Flynn JS, Su Y, Zhang H, Russell KM, Schenk LAM, Schover L. Patient factors associated with sperm cryopreservation among at-risk adolescents newly diagnosed with cancer. Cancer, In Press.

Kumar AJ, Kim S, Hemmer MT, Arora M, Spellman SR, Pidala JA, Couriel DR, Alousi AM, Aljurf MD, Cahn JY, Cairo MS, Cutler CS, Farhan S, Gergis U, Hale GA, Hashmi SK, Inamoto Y, Kamble RT, Kharfan-Dabaja MA, MacMillan ML, Marks DI, Nakasone H, Norkin M, Qayed M, Ringden O, Schouten HC, Schultz KR, Solh MM, Teshima T, Urbano-Ispizua A, Verdonck LF, Gale RP, Hamilton BK, Majhail NS, Loren AW. Graft-versus-host disease in recipients of male unrelated donor compared with parous female sibling donor transplants. Blood Adv. 2018 May 8;2(9):1022-1031. doi: 10.1182/bloodadvances.2017013052. PubMed PMID: 29739773; PubMed Central PMCID: PMC5941995.

Lee JA, Wang Z, Sambo D, Bunting KD and Pallas DC (2018) “Global loss of leucine carboxyl methyltransferase-1 causes severe defects in fetal liver hematopoiesis.” Journal of Biological Chemistry, May 7, 2018. (Epub ahead of print). PMID: 29735529

Lehmann V, Flynn JS, Foster RH, Russell KM, Klosky JL. Accurate understanding of infertility risk among families of adolescent males newly diagnosed with cancer. Psycho-Oncology, In Press.

Lehmann V, Nahata L, Ferrante AC, Hansen-Moore JA, Jaeger ND, Klosky JL, Gerhardt CA. Fertility-related perceptions and impact on romantic relationships among adult survivors of childhood cancer. Journal of Adolescent and Young Adult Oncology, In Press.

Lesmana H, Dyer L, Zhou P, Li X, Denton J, Chonat S, et al. Alu-element insertion in PKLR gene as a novel cause of pyruvate kinase deficiency in Middle Eastern patients.. Hum Mutat. 2018 Mar;39(3):389-393

Maier CL, Gross PJ, Dean CL, Chonat S, et al. Transfusion-Transmitted Malaria Masquerading as Sickle Cell Crisis with Multisystem Organ Failure. Transfusion. 2018 Mar 9. doi: 10.1111/trf.14566. [Epub ahead of print]

Major-Monfried H, Renteria AS, Pawarode A, Reddy P, Ayuk F, Holler E, Efebera YA, Hogan WJ, Wölfl M, Qayed M, Hexner EO, Wudhikarn K, Ordemann R, Young R, Shah J, Hartwell MJ, Chaudhry MS, Aziz M, Etra A, Yanik GA, Kröger N, Weber D, Chen YB, Nakamura R, Rösler W, Kitko CL, Harris AC, Pulsipher M, Reshef R, Kowalyk S, Morales G, Torres I, Özbek U, Ferrara JLM, Levine JE. MAGIC biomarkers predict long-term outcomes for steroid-resistant acute GVHD. Blood. 2018 Mar 15. pii: blood-2018-01-822957. doi: 10.1182/blood-2018-01-822957. [Epub ahead of print] PubMed PMID: 29545329.

Malik R, Chauhan G, Traylor M, Sargurupremraj M, Okada Y, Mishra A, Rutten-Jacobs L, Giese AK, van der Laan SW, Gretarsdottir S, Anderson CD, Chong M, Adams HHH, Ago T, Almgren P, Amouyel P, Ay H, Bartz TM, Benavente OR, Bevan S, Boncoraglio GB, Brown, Jr. RD, Butterworth AS, Carrera C, Carty CL, Chasman DI, Chen WM, Cole JW, Correa A, Cotlarciuc I, Cruchaga C, Danesh J, de Bakker PIW, DeStefano AL, den Hoed M, Duan Q, Engelter ST, Falcone GJ, Gottesman RF, Grewal RP, Gudnason V, Gustafsson S, Haessler J, Harris TB, Hassan A, Havulinna AS, Heckbert SR, Holliday EG, Howard G, Hsu FC, Hyacinth HI, Ikram MA, Ingelsson E, Irvin MR, Jian X, Jiménez-Conde J, Johnson JA, Jukema JW, Kanai M, Keene KL, Kissela BM, Kleindorfer DO, Kooperberg C, Kubo M, Lange L, Langefeld CD, Langenberg C, Launer LJ, Lee JM, Lemmens R, Leys D, Lewis CM, Lin WY, Lindgren AG, Lorentzen E, Magnusson PK, Maguire J, Manichaikul A, McArdle PF, Meschia JF, Mitchell BD, Mosley TH, Nalls MA, Ninomiya T, O'Donnell MJ, Psaty BM, Pulit SL, Rannikmäe K, Reiner AP, Rexrode KM, Rice K, Rich SS, Ridker PM, Rost NS, Rothwell PM, Rotter JI, Rundek T, Sacco RL, Sakaue S, Sale MM, Salomaa V, Schmidt R, Schmidt CO, Schminke U, Sharma P, Slowik A, Sudlow CLM, Tanislav C, Tatlisumak T, Taylor KD, Thijs VNS, Thorleifsson G, Thorsteinsdottir U, Tiedt S, Trompet S, Tzourio C, van Duijn CM, Walters M, Wareham NJ, Wassertheil-Smoller S, Wilson JG, Wiggins KL, Yang Q, Yusuf S, AFGen consortium, Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium, International Genomics of Blood Pressure (iGEN-BP) Consortium, INVENT consortium, STARNET, Bis JC, Pastinen T, Ruusalepp A, Schadt EE, Koplev S, Björkegren JLM, Codoni V, Civelek M, Smith N, Trégouët DA, Christophersen IE, Roselli C, Lubitz SA, Ellinor PT, Tai ES, Kooner JS, Kato N, He J, van der Harst P, Elliott P, Chambers JC, Takeuchi F, BioBank Japan Cooperative Hospital Group, COMPASS consortium, EPIC-CVD consortium, EPIC-InterAct consortium, International Stroke Genetics Consortium (ISGC), METASTROKE Consortium, Neurology Working Group of the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium, NINDS Stroke Genetics Network (SiGN), UK Young Lacunar DNA Study, Sanghera DK, Melander O, Jern C, Strbian D, Fernandez-Cadenas I, Longstreth, Jr. WT, Rolfs A, Hata J, Woo D, Rosand J, Pare G, Hopewell JC, Saleheen D, Stefansson K*, Worrall BB*, Kittner SJ*, Seshadri S*, Fornage M*, Markus HS*, Howson JMM*, Kamatani Y*, Debette S*§ and Dichgans M*§. Multi-ancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes. Nature Genetics. 2018 Apr;50(4):524-537

Marchetti C, Swartzwelter B, Gamboni F, Neff C, Richter K, Azam T, Carta S, Tengesdal I, Nemkov T, D-Alessandro A, Henry C, Jones G, Goodrich S, Laurent J, Jones T, Scribner C, Barrow R, Altman R, Skouras D, Gattorno M, Grau V, Janciauskiene S, Rubartelli A, Joosten L, and Dinarello C.  OLT1177, a β‑sulfonyl Nitrile Compound Safe in Humans, Inhibits the NLRP3 Inflammasome and Reverses the Metabolic Cost of Inflammation.  Proceedings of the National Academy of Sciences. 2018. Feb 13; 115(7):E1530-E1539.

Martin, SR, Cohen, LL, Mougianis, I, Griffin, A, Sil, S, Dampier, C. (2018) Pain and Stigma in Adolescents Hospitalized for Sickle Cell Vaso-occlusive Episodes. Clin J Pain. 34(5):438-444. doi: 10.1097/AJP.0000000000000553.

Maude SL, Laetsch TW, Buechner J, Rives S, Boyer M, Bittencourt H, Bader P, Verneris MR, Stefanski HE, Myers GD, Qayed M, De Moerloose B, Hiramatsu H, Schlis K, Davis KL, Martin PL, Nemecek ER, Yanik GA, Peters C, Baruchel A, Boissel N, Mechinaud F, Balduzzi A, Krueger J, June CH, Levine BL, Wood P, Taran T, Leung M, Mueller KT, Zhang Y, Sen K, Lebwohl D, Pulsipher MA, Grupp SA. Tisagenlecleucel

in Children and Young Adults with B-Cell Lymphoblastic Leukemia. N Engl J Med. 2018 Feb 1;378(5):439-448. doi: 10.1056/NEJMoa1709866. PubMed PMID: 29385370.

Metts JL, Alazraki AL, Clark D, Amankwah EK, Wasilewski-Masker KJ, George BA, Olson TA, Cash T.Gemcitabine/nab-paclitaxel for pediatric relapsed/refractory sarcomas.Pediatr Blood Cancer. 2018 May 17:e27246. doi: 10.1002/pbc.27246. [Epub ahead of print] PMID: 29770997

Metts JL, Park SI, Briones MA, Keller FG. Hemophagocytic Lymphohistiocytosis Secondary to T Cell/Histiocyte-rich Large B Cell Lymphoma in an Adolescent Male. Pediatr Dev Pathol. 2018 Jan-Feb;21(1):95-99. PMID:29187030

Morgan TM, Danish H, Nanda R, Esiashvili N and Meacham LR. Whole Lung Irradiation in Stage IV Wilms Tumor Patients: thyroid Dosimetry and Outcomes. 2017 Pediatr Blood Cancer. 2018 Feb;65(2). doi: 10.1002/pbc.26843. Epub 2017 Sep 27.PMID:28960781

Otsuru S, Desbourdes L, Guess AJ, Hofmann TJ, Relation T, Kaito T, Dominici M, Iwamoto M, Horwitz EM. Extracellular Vesicles Released from Mesenchymal Stem/Stromal Cells Stimulate Bone Growth in Osteogenesis Imperfecta, Cytotherapy, 20:62-73, 2018.

Pai, A.L.H., Rausch, J., Drake, S., Morrison, C.F., Lee, J.L., Nelson, A…& Davies, S. (2018).  Poor adherence is associated with more infections following pediatric hematopoietic stem cell transplant. Biology of Blood and Marrow Transplantation, 24(2), 381-385. doi: 10.1016/j.bbmt.2017.10.033 

Parsons SK, Kelly MJ, Cohen JT, Castellino SM, Henderson TO, Kelly KM, Keller FG, Henzer TJ, Kumar AJ, Johnson P, Meyer RM, Radford J, Raemaekers J, Hodgson DC, Evens AM. Early-stage Hodgkin lymphoma in the modern era: simulation modelling to delineate long-term patient outcomes.Br J Haematol. 2018 Apr 29 PMID:29707774

Pashankar F, Frazier AL, Krailo M, Xia C, Pappo AS, Malowlogowkin M, Olson TA, Rodriguez-Galindo C.      Treatment of Refractory Germ Cell Tumors in Children with Paclitaxel and Carboplatin: A Report from the Children’s Oncology Group AGCT9521 Study. Pediatr Blood and Cancer (in press).

Patel SR, Bennett A, Girard-Pierce K, Maier CL, Chonat S et al. Recipient priming to one RBC alloantigen directly enhances subsequent alloimmunization in mice. Blood Adv, 2018 Jan 23;2(2):105-115

Pena LDM, Jiang YH, Schoch K, Spillmann RC, Walley N, Stong N, Rapisardo Horn S, Sullivan JA, McConkie-Rosell A, Kansagra S, Smith EC, El-Dairi M, Bellet J, Keels MA, Jasien J, Kranz PG, Noel R, Nagaraj SK, Lark RK, Wechsler DSG, Del Gaudio D, Leung ML, Hendon LG, Parker CC, Jones KL; Undiagnosed Diseases Network Members, Goldstein DB, Shashi V. Looking beyond the exome: a phenotype-first approach to molecular diagnostic resolution in rare and undiagnosed diseases. Genetics in Medicine 20(4):464-469, 2018.  PMID: 28914269

Qayed M, Wang T, Hemmer MT, Spellman S, Arora M, Couriel D, Alousi A, Pidala J, Abdel-Azim H, Aljurf M, Ayas M, Bitan M, Cairo M, Choi SW, Dandoy C, Delgado D, Gale RP, Hale G, Frangoul H, Kamble RT, Kharfan-Dabaja M, Lehman L, Levine J, MacMillan M, Marks DI, Nishihori T, Olsson RF, Hematti P, Ringden O, Saad A, Satwani P, Savani BN, Schultz KR, Seo S, Shenoy S, Waller EK, Yu L, Horowitz MM, Horan J. Influence of Age on Acute and Chronic GVHD in Children Undergoing HLA-Identical Sibling Bone Marrow Transplantation for Acute Leukemia: Implications for Prophylaxis. Biol Blood Marrow Transplant. 2018 Mar;24(3):521-528. doi: 10.1016/j.bbmt.2017.11.004. Epub 2017 Nov 16. PubMed PMID: 29155316; PubMed Central PMCID: PMC5826854.

Qiu Y, Ahn B, Sakurai Y, Hansen CE, Tran R, Mimche PN, Mannino RG, Lamb TJ, Joiner CH, Ofori-Acquah SF, Lam WA. “Microvasculature-on-a-chip for the long-term study of endothelial barrier dysfunction and microvascular obstruction in disease” Nature Biomoedical Engineering (in press)

Quach ME, Dragovich MA, Chen W, et al. Fc-independent immune thrombocytopenia via mechanomolecular signaling in platelets. Blood. 2018;131(7):787-796

Raikar SS, Park, SI, Leong T, Jay DL, Keller FG, Horan JT and Woods WG; Isolated myeloperoxidase expression in pediatric B/Myeloid mixed phenotype acute leukemia is linked with better prognosis.  Blood 2018; 31: 573-577.

Raikar SS, Felker J, Patel KN, Lew G, Sidonio RF Jr. Acquired Hypofibrinogenemia Before Asparaginase Exposure During Induction Therapy for Pediatric Acute Lymphoblastic Leukemia: A Report of 2 Cases and Review of the Literature. J Pediatr Hematol Oncol. 2018 Feb 2. doi: 10.1097/MPH.0000000000001114. [Epub ahead of print] PMID: 29401102

Reeve BB, Edwards LJ, Jaeger BC, Hinds PS, Dampier C, Gipson DS, Selewski DT, Troost JP, Thissen D, Barry V, Gross HE, DeWalt DA. (2018) Assessing Responsiveness over Time of the PROMIS® Pediatric Symptom and Function Measures in Cancer, Nephrotic Syndrome, and Sickle Cell Disease. Qual Life Res. 27(1):249-257. doi: 10.1007/s11136-017-1697-z.

Relation T, Yi T, Guess AJ, La Perle K, Otsuru S, Dominici M, Breuer C, Horwitz EM. Intratumoral Delivery of Interferon γ-secreting MSCs Repolarizes Tumor-Associated Macrophages and Suppresses Neuroblastoma Proliferation In Vivo. Stem Cells, Stem Cells. 2018 Feb 12. doi: 10.1002/stem.2801. [Epub ahead of print] PMID: 29430789.

Risinger M, Glogowska E, Chonat S, et al. Hereditary xerocytosis: Diagnostic considerations. Am J Hematol. 2018 Mar;93(3):E67-E69

Rossignoli F, Grisendi G, Spano C, Golinelli G, Recchia A, Rovesti G, Orsi G, Veronesi E, Horwitz EM, Dominici M. Inducible Caspase9-mediated Suicide Gene for MSC-based Cancer Gene Therapy. Cancer Gene Therapy, in press, 2018. (just accepted, not even an epub yet)

Runco DV, Josephson CD, Raikar SS, Goldsmith KC, Lew G, Pauly M, Fasano RM. Hyperleukocytosis in infant acute leukemia: a role for manual exchange transfusion for leukoreduction. Transfusion. 2018 May;58(5):1149-1156. doi: 10.1111/trf.14512. Epub 2018 Feb 4. PubMed PMID: 29399859; PubMed Central PMCID: PMC5912979.

Sagiv E*, Fasano RM*, Luban NLC, Josephson CD, Stowell SR, Roback JD, Francis RO, Yee MEM. Glucose-6-Phosphate-Dehydrogenase Deficient Red Blood Cell Units are Associated with Decreased Post-Transfusion Red Blood Cell Survival in Children with Sickle Cell Disease. American Journal of Hematology. 2018 May;93(5):630-634. *co-first authors.

Sagiv E, Fasano RM, Luban NLC, Josephson CD, Stowell SR, Roback JD, Francis RO, Yee MEM. Glucose-6-Phosphate-Dehydrogenase Deficient Red Blood Cell Units are Associated with Decreased Post-Transfusion Red Blood Cell Survival in Children with Sickle Cell Disease.  Am J Hematol. 2018 Jan 27. doi: 10.1002/ajh.25051. [Epub ahead of print]  PMID:  29377292. 

Sam SS, Ingersoll J, Racsa LD, Caliendo AM, Racsa PN, Igwe D, Abdul-Ali D, Josephson C, Kraft CS. Long-term stability of CMV DNA in human breast milk. J Clin Virol. 2018 May;102:39-41. doi: 10.1016/j.jcv.2018.02.014. PMID: 2948638.

Sakurai Y, Hardy ET, Ahn B, Tran R, Fay ME, Ciciliano JC, Mannino RG, Myers DR, Qiu Y, Carden MA, Baldwin WH, Meeks SL, Gilbert GE, Jobe SM, Lam WA. “A microengineered vascularized bleeding model that integrates the principal components of hemostasis.” Nature Communications. 2018 Feb 6;9(1):509.

Schroeder KM, Saxton A, McDade J, Chao C, Masalu N, Chao C, Wechsler DS, Chao N and Likonda B. Pediatric Cancer in Northern Tanzania: Evaluation of Diagnosis, Treatment and Outcomes. Journal of Global Oncology 4:1-10, 2018.

Shah R, Xia C, Krailo M, Amatruda JF, Arul SG, Billmire DF, Brady WE, Covens A, Gershensen DM, Hale JP, Hurteau J, Murray MJ, Nicholson JC, Olson TA, Pashankar F, Rodrigues-Galindo C, Shaikh F, Frazier AF, Stoneham S. Is carboplatin-based chemotherapy as effective as cisplatin-based chemotherapy in the treatment of advanced-stage dysgerminoma in children, adolescents and young adults. Gynecologic Oncology (in press).

Shih AY, Hyacinth HI, Hartman AD, van Veluw S. Rodent models of cerebral microinfarcts and microhemorrhages. Stroke. 2018 Mar;49(3):803-810

Smart LR, Ambrose EE, Raphael KC, Hokororo A, Kamugisha E, Tyburski EA, Lam WA, Ware RE, McGann PT. “Simultaneous point-of-care detection of anemia and sickle cell disease in Tanzania: the RAPID study.” Ann Hematol. 2018 Feb;97(2):239-246

Stavrou E. X., C. Fang, K. L. Bane, E. Kucukal, L. V. Nayak, A. Merkulova, S. Izadmehr, M. M. Mumaw, C. C. Reynolds, O. Alhalabi, W. M. Yu, C. K. Qu, U. A. Gurkan, H. J. Meyerson, M. T. Nieman, A. H. Schmaier. Factor XII - uPAR Upregulate Neutrophil Functions to Influence Wound Healing. The Journal of Clinical Investigation. 2018; 128:944-959

Summers RJ, Metrock LK Park S, Gillespie S, Castellino S, Lew G, Keller FG. Comment on: Value of flow cytometric analysis of peripheral blood samples in children diagnosed with acute lymphoblastic leukemia. Pediatr Blood Cancer. 2018 Feb;65(2). Doi: 10.1002/pbc.26845.

Summers RJ, Minson KM, DeRyckere D, and Graham DK. Roles for AXL and MERTK in Resistance to Cytotoxic and Targeted Therapies. In: Johnson D, ed. Targeting Cell Survival Pathways to Enhance Response to Chemotherapy. 1st ed. San Diego, CA: Academic Press; 2018.

Tarnawsky S.P., R. J. Chan, W. M. Yu, C. K. Qu, M. C. Yoder. Hematopoietic-restricted Ptpn11 E76K reveals indolent MPN progression. Oncotarget. 2018; 9:21831-21843

Walco GA, Kopecky EA, Weisman SJ, Stinson J, Steven B, Desjardins P, Berde CB, Krane EJ, Anand KJS, Yaster M, Dampier CD, Dworkin R, Gilron I, Lynna A, Maxwell L, McDermot M, Raja S, Schachtel B, Turk D (2018) Clinical Trial Designs and Models for Analgesic Medications for Acute Pain in Neonates, Infants, Toddlers, Children, and Adolescents: ACTTION Recommendations, Pain. 159(2):193-205.doi: 10.1097/j.pain.0000000000001104.

Yee MEM, Josephson CD, Winkler AM, Webb J, Luban NLC, Leong T, Stowell SR, Roback JD, Fasano RM. Hemoglobin A Clearance in Children with Sickle Cell Anemia on Chronic Transfusion Therapy. Transfusion. 2018 Apr 17 Epub ahead of print. PMID: 29664198.

Yee MEM, Lane PA, Archer DR, Joiner CH, Eckman JR, Guasch A. Losartan Therapy Decreases Albuminuria with Stable Glomerular Filtration and Permselectivity in Sickle Cell Anemia. Blood Cells, Molecules & Diseases. 2018 Mar;69:65-70. PMID: 28951038.

Zhang Y, Qiu Y, Blanchard AT, Chang Y, Brockman JM, Ma VP, Lam WA*, Salaita K*. “Platelet integrins exhibit anisotropic mechanosensing and harness piconewton forces to mediate platelet aggregation.” Proc Natl Acad Sci U S A. 2018 Jan 9;115(2):325-330. *co-corresponding authors

Zheng H., W. M. Yu, R. R. Waclaw, M. I. Kontaridis, B. G. Neel, and C. K. Qu*. Gain-of-function mutations in protein tyrosine phosphatase Ptpn11 (Shp2) induce hydrocephalus in a catalytically-dependent manner. Science Signaling. 2018; 11 (522), eaao1591.

  • Renhao Li, PhD, received a score of 6% on his R01 entitled “Conformational activation of von Willebrand factor.”  The proposed start date of funding is 7/1. (Pete Lollar is a co-investigator on this grant)
  •  Robert Schnepp, MD, PhD, received  a 2018 Sarcoma Foundation of America grant for his proposal “BMI1 as a Novel Driver and Target in Alveolar Rhabdomyosarcoma”
  •  Robert Sidonio, Jr., MD, MSc, will be PI for a multimillion $ Genentech Hemlibra (emicizumab) study based here at Aflac
  • Shannon Meeks and Sean Stowell are principal investigators on a new NIH R01 award, entitled “Defining Initiating Factors Responsible for the Development of FVIII Inhibitors”, which will begin on June 1.
  • Along with the Children’s Hospital of Philadelphia/University of Pennsylvania and Temple University, Emory was one of three institutions selected by the NIH to become a Center for the Investigation of Factor VIII Immune Response in Patients with Hemophilia A. This is a five-year award funded through the NIH U54 mechanism
  • Wilbur Lam who learned (the week of June 23) that a U54 he submitted with Georgia Tech (and the help of Stacy Heilman) will be funded – this is a >$7M grant that is focused on Point of Care (POC) technologies for cardiac, pulmonary, hematologic, and sleep applications
  • Cheng-Kui Qu and Muxiang Zhou each received a grant from the Rally Foundation to support their research
  • Wilbur Lam will be PI on an R01 (“A microfluidics-based paradigm for clinical lentivector gene transfer”) and an R21 (“Leveraging microfluidic technologies and cell-scale simulations to investigate sickle cell vasculopathy”)
  • Ann Mertens received a R01 with a colleague from Rollins to study the SurvivorLink system
  • Kelly Goldsmith and Wait Aumann on receiving two-year Hyundai Hope ($300K) and Young Investigator ($200K) grants, respectively
  • Peter Lane and Krish received $1.2M and $1.5M three-year grants, respectively, from the Katz Foundation
  • Ryan Summers awarded a two year, $195K, St. Baldrick’s Fellow Award
  • Jordan Marchak on receiving a $50K Winship Invest$ Cancer Prevention & Control Research Grant on “Validating Electronic Distress Screening in Pediatric Oncology”
  • Sunil Raikar and Shan Chandrakasan on being selected to be Scholars on the Departmental K12 grant
  • Curtis Henry and Katherine Minson who were each recently awarded a Winship American Cancer Society Institutional Research Grant to support their research
  • Wilbur Lam on receiving an NIH R21 to support a project focused on a smartphone app to non-invasively measure Hgb levels