Renhao Li, PhD
Department of Pediatrics
Division of Hematology/Oncology
Emory University School of Medicine
I am interested in how cell adhesion receptors detect the extracellular stimulation and help to determine the response of their host cells. Our approach is multidisciplinary, using a combination of cell biological, biochemical, and biophysical techniques.
One of our current studies focuses on the structure/function of the platelet glycoprotein (GP) Ib-IX-V complex that is involved in platelet activation, aggregation, genesis and clearance. The interaction between the GP Ib-IX-V complex in platelets and von Willebrand Factor immobilized on the injury site in the artery is widely considered as the first step for hemostasis. We aim to understand how the subunits in this complex interact with one another and assemble into a functional entity. The insights on the organization of the Ib-IX-V complex will help us define the mechanism by which this complex mediates signals across the membrane to activate the platelet, identify the factors regulating its synthesis and breakdown, and understand its interaction with extracellular and intracellular binding partners including disease-causing autoantibodies.