Overview
The overarching goal of my research program is to utilize behavioral means to reduce health risks among survivors of childhood cancer. As a Professor in the Department of Pediatrics at Emory University School of Medicine, I have developed a program of research in this regard focusing on the following primary objectives:
1.) Characterization and prediction of risky health behaviors in survivors of childhood cancer
2.) Utilization of behaviorally-mediated strategies to a) control, and b) prevent second cancers in adolescent and young adult survivors of childhood cancer.
To pursue these objectives, I actively investigate the relations between psychological factors (e.g. health belief, cognitive-motivational, social learning) and health behaviors (e.g. risky sexual behaviors, HPV vaccination, fertility preservation, sexual functioning), and have subsequently designed and tested interventions aimed at modifying psychological factors as a mechanism for behavior change. Working within a developmental framework, this approach has been tested in child and adolescent cancer survivors as a means of delaying or preventing risky health behaviors in adolescence and young adulthood.
NIH Funded
NCI U01 – PENDING
Implementation of a Provider-Focused Intervention for Maximizing HPV Vaccine Uptake in Young Cancer Survivors receiving Follow-Up Care in Pediatric Oncology Practices: A Cluster-Randomized Trial
NCI R01 – PENDING
Enhancing Clinical Trial Availability, Access, and Enrollment for Adolescents and Young Adults with Cancer
NCI U01 CA243688 – 09/18/2019-8/31/2024
The AYA-RISE Intervention: Risk Information and Screening Education for Adolescents and Young Adults with Cancer Predisposition Syndromes
NCI R25 CA142519 – 04/01/2015-03/31/2021
Enriching Communication Skills of Health Professionals in Oncofertility
NCI K08 CA237338 – 04/01/2019-03/31/2024
Optimizing Fertility Preservation & Decision Quality in Male AYAs with Cancer: A Family-Centered Intervention
Foundation Funded
Pediatric Cancer Research Foundation
Assessing Patient Preferences and an Existing Tool for Screening for Sexual Dysfunction in Adolescent and Young Adult Survivors of Childhood Cancer
America Family Life Assurance Company Foundation
Distress in the Pediatric Oncology Setting: Intervention Versus Natural Adaptation – A Multi-Center Study
Brooke Cherven, PhD, MPH, RN, CPON, Assistant Professor, Pediatric Hematology/Oncology
Education: BSN, University of Michigan; MPH, Emory University; PhD, University of Alabama at Birmingham
Doctoral Dissertation: Sexual behaviors and human papillomavirus non-initiation among young adult cancer survivors
K23 Career Development Award with mentorship provided by Dr. Klosky
Email: brooke.cherven@emory.edu
Joanna Buscemi, PhD, Assistant Professor, DePaul University
Ashley Hum Clawson, PhD, Assistant Professor, Oklahoma State University
Michael McDermott, PhD, Assistant Professor, University of Louisiana at Lafayette
Courtney Peasant Bonner, PhD, RTI International
Kelly Peck, PhD, Assistant Professor of Psychology & Psychiatry, University of Vermont
Rebecca Foster, PhD, Assistant Professor, Washington University School of Medicine
Vicky Lehmann, PhD, Faculty Researcher, Amsterdam University Medical Center
Select High Impact Publications over the last 10 years
Lehmann V, Chemaitilly W, Lu L, Green DM, Kutteh WH, Brinkman TM, Srivastava DK, Robison LL, Hudson MM, Klosky JL. Gonadal functioning and perceptions of infertility risk among adult survivors of childhood cancer: A report from the St. Jude Lifetime Cohort Study. Journal of Clinical Oncology, 37:893-902, 2019.
Van Iersel L, Li Z, Chemaitilly W, Ness KK, Hudson MM, Klosky JL. Erectile dysfunction in male survivors of childhood cancer: A report from the St. Jude Lifetime Cohort Study. JAMA Oncology, 4:1613-1616, 2018.
Klosky JL, Lehmann V, Flynn JS, Su Y, Zhang H, Russell KM, Schenk LAM, Schover L. Patient factors associated with sperm cryopreservation among at-risk adolescents newly diagnosed with cancer. Cancer, 124:3567-3575, 2018.
Klosky JL, Wang F, Russell KM, Zhang H, Flynn JS, Huang L, Wasilewski-Masker K, Landier W, Leonard M, Albritton KH, Gupta AA, Casillas J, Colte P, Kutteh WH, & Schover LR. Prevalence and predictors of sperm banking in adolescents newly diagnosed with cancer: Examination of adolescent, parent, and provider factors influencing fertility preservation outcomes. Journal of Clinical Oncology, 35:3830-3836, 2017.
Klosky JL, Hudson MM, Chen Y, Connelly JA, Wasilewski-Masker K, Sun CL, Francisco LM, Gustafson L, Russell KM, Sabbatini G, Simmons JL, York JM, Giuliano AR, Robison LL, Wong FL, Bhatia S, & Landier W. Human Papillomavirus (HPV) vaccination rates in young cancer survivors. Journal of Clinical Oncology, 35:3582-3590, 2017.
Klosky JL, Krull KR, Kawashima T, Leisenring W, Randolph ME, Zebrack B, Stuber ML, Robison LL & Phipps S. Relations between posttraumatic stress and posttraumatic growth in long-term survivors of childhood cancer. A report from the Childhood Cancer Survivor Study. Health Psychology, 33:878-882, 2014.
Klosky JL, Foster RH, Li Z, Peasant C, Howell C, Mertens AC, Robison LL & Ness KK. Risky sexual behavior in adolescent survivors of childhood cancer: A report from the childhood cancer survivor study. Health Psychology, 33:868-877, 2014.
Klosky JL, Hum AM, Zhang N, Ali KS, Srivastava DK, Klesges RC, Emmons KM, Ness KK, Stovall M, Robison LL & Hudson MM. Smokeless and dual tobacco use among males surviving childhood cancer: A report from the Childhood Cancer Survivor Study. Cancer Epidemiology, Biomarkers & Prevention, 22:1025-1029, 2013.
Klosky JL**, Howell C, Li Z, Foster RH, Mertens AC, Robison LL, & Ness KK. Risky health behavior among adolescents in the Childhood Cancer Survivor Study cohort. Journal of Pediatric Psychology, 37:634-646, 2012. **Accompanied by editorial and included in the 2015 40th Anniversary Collection as being one of the Top 10 most cited articles in the history of Journal of Pediatric Psychology.
Klosky JL, Tyc VL, Hum A, Lensing S, Buscemi J, Garces-Webb DM, & Hudson MM. Establishing the predictive validity of intentions to smoke among preadolescents and adolescents surviving childhood cancer. Journal of Clinical Oncology, 28:431-436, 2010.
NIH Funded:
NCI U01 CA243688 – 09/18/2019-8/31/2024
The AYA-RISE Intervention: Risk Information and Screening Education for Adolescents and Young Adults with Cancer Predisposition Syndromes
Goal: Develop, implement and test a web-based AYA-specific intervention for cancer risk communication and decision-making. Specific aims of this type I hybrid implementation effectiveness trial include refining and piloting AYA-RISE, testing the impact of the intervention with regards to patient knowledge, psychological distress, patient ownership of information, and follow-up for recommended care, along with evaluation of implementation outcomes.
Role: Co-I
PI: Mack
NCI K08 CA237338 – 04/01/2019-03/31/2024
Optimizing Fertility Preservation & Decision Quality in Male AYAs with Cancer: A Family-Centered Intervention
Goal: Develop and test a novel family-centered psychoeducational intervention for AYA males prior to cancer treatment to optimize fertility preservation uptake and decision quality.
Role: Mentor
PI: Nahata
NCI R25 CA142519 – 04/01/2015-03/31/2021
Enriching Communication Skills of Health Professionals in Oncofertility (ECHO)
Goal: Train nurses, social workers, psychologists, and physician assistants to address reproductive health concerns among AYA oncology patients via a web based learning community, and to evaluate the impact of the program at the participant and workplace level.
Role: Consultant
MPI: Quinn/Vadaparampil
Foundation Funded:
Pediatric Cancer Research Foundation
Assessing Patient Preferences and an Existing Tool for Screening for Sexual Dysfunction in Adolescent and Young Adult Survivors of Childhood Cancer
Role: Co-I
PI: Sopfe
America Family Life Assurance Company Foundation
Distress in the Pediatric Oncology Setting: Intervention Versus Natural Adaptation – A Multi-Center Study
Role: Co-I
PI: Miller
Quoted in U.S. News & World Report on fertility preservation
Featured in TIME and BBC News for research in breast feeding among mothers surviving childhood cancer
Videos
Interview with Oncology Nursing News – “HPV-Related Cancer in Childhood Cancer Survivors”