Faculty Directory

Biography

We are interested in how cells ensure accurate segregation of chromosomes during the cell division cycle and how this process go awry in cancer cells. Microtubules play crucial roles in ensuring the fidelity of chromosome segregation in dividing cells and in the elaboration and maintenance of axons and dendrites of post-mitotic neurons. We are using molecular and genetic approaches to understand fundamental mechanisms of microtubule functions in both the normal cell division in healthy cells and the abnormal divisions in cancer cells. We are also taking advantage of our knowledge to design novel small molecules to intervene diseased conditions such as cancer.

Research

Cell Biology
Molecular motors and cytoskeletal control of the cell cycle
Intra- and inter-cellular signaling cascades
Organelle structure and function

Developmental biology
Genetic analysis of development
Specification of cell lineages
Cell interactions during fertilization and development

Neurobiology
Developmental neurobiology
Sensory and musculo-skeletal neurobiology
Neuro degeneration and repair