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Barbara D Boyan, PhD

Barbara D. Boyan, PhD headshot

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PubMed

Biography

Areas of Research

  • Mechanism of action of hormones and growth factors in chondrocytes and osteoblasts
  • Normal and pathological calcification
  • Tissue engineering
  • Response of cells to biomaterials

Educational Background

  • Ph.D., Rice University, 1975
  • M.A., Rice University, 1974
  • B.A., Rice University, 1970

Selected Awards

  • Fellow, American Institute of Mechanical and Biological Engineering, 2006
  • Atlanta Woman of the Year (Science), 2005
  • The Birnberg Research Award, Columbia University School of Dental and Oral Surgery, 2003
  • Fellow, American Association for the Advancement of Science, 2002
  • Society for Biomaterials Clemson Award for Contributions to the Literature, 2001
  • Albert-Hoffa-Prize (with Drs CH Lohmann, Z Schwartz, Y Liu, H Guerkov, B Simon, BD Boyan), Die Norddeutsche Orthop denvereinigung e.V (North German Orthopaedic Society) Research Prize, 2001
  • American Academy of Periodontolgy, R. Earl Robinson Regeneration Award (with Drs Z Schwarts, DD Dean, CH Lohmann, D Andreacchio, TC Weesner, DL Carnes, DL Cochran), October, 2001

Selected Research Publications

  • Singh KA, Moyer H, Williams JK, Schwartz Z, Boyan, BD. Fibrin Glue, A scaffold for Cellular-Based Therapy in a Critical-Sized Defect. Annals of Plastic Surgery. 2011 March; 66(3):1-5. [ahead of printing]
  • Raines AL, Sunwoo M, Gertzman AA, Thacker K, Guldberg RE, Schwartz Z, Boyan BD. Hyaluronic acid stimulates neovascularization during the regeneration of bone marrow after ablation. J Biomed Mater Res A. 2011 Jan 10. [Epub ahead of print] PubMed PMID: 21225712.
  • Zhong M, Carney DH, Jo H, Boyan BD, Schwartz Z. Inorganic Phosphate Induces Mammalian Growth Plate Chondrocyte Apoptosis in a Mitochondrial Pathway Involving Nitric Oxide and JNK MAP Kinase. Calcif Tissue Int. 2010 Nov 23. [Epub ahead of print] PubMed PMID: 21104071.
  • Zhong M, Carney DH, Boyan BD, Schwartz Z. 17β-Estradiol regulates rat growth plate chondrocyte apoptosis through a mitochondrial pathway not involving nitric oxide or MAPKs. Endocrinology. 2011 Jan;152(1):82-92. Epub 2010 Nov 10. PubMed PMID: 21068162.
  • Moyer HR, Wang Y, Farooque T, Wick T, Singh KA, Xie L, Guldberg RE, Williams JK, Boyan BD, Schwartz Z. A new animal model for assessing cartilage repair and regeneration at a nonarticular site. Tissue Eng Part A. 2010 Jul;16(7):2321-30.PubMed PMID: 20192719.
  • Moyer HR, Kinney RC, Singh KA, Williams JK, Schwartz Z, Boyan BD. Alginate microencapsulation technology for the percutaneous delivery of adipose-derived stem cells. Ann Plast Surg. 2010 Nov;65(5):497-503. PubMed PMID: 20842001.
  • Wang Y, Chen J, Lee CS, Nizkorodov A, Riemenschneider K, Martin D, Hyzy S, Schwartz Z, Boyan BD. Disruption of Pdia3 gene results in bone abnormality and affects 1alpha,25-dihydroxy-vitamin D3-induced rapid activation of PKC. J Steroid Biochem Mol Biol 2010 121(1-2):257-60.
  • Wang Y, Bella E, Lee CS, Migliaresi C, Pelcastre L, Schwartz Z, Boyan BD, Motta A. The synergistic effects of 3-D porous silk fibroin matrix scaffold properties and hydrodynamic environment in cartilage tissue regeneration. Biomaterials 31:4672-4681, 2010. Epub 3/19, 2010.
  • Boyan BD, Hurst-Kennedy J, Denison TA, Schwartz Z.  24R,25-Dihydroxyvitamin D3 [24R,25(OH)(2)D(3)] controls growth plate development by inhibiting apoptosis in the reserve zone and stimulating response to 1alpha,25(OH)(2)D(3) in hypertrophic cells. J Steroid Biochem Mol Biol. 2010 Jul;121(1-2):212-6. Epub 2010 Mar 20. PubMed PMID: 20307662.
  • Raines AL, Olivares-Navarrete R, Wieland M, Cochran DL, Schwartz Z, Boyan DB. Regulation of angiogenesis during osseointegration by titanium surface microstructure and energy. Biomaterials 31:4909-4917, 2010. Epub 3/30, 2010.
  • Lee CS, Moyer HR, Gittens RA, Williams JK, Boskey AL, Boyan BD, Schwartz Z.  Regulating in vivo calcification of alginate microbeads. Biomaterials 31:4926-4934, 2010. Epub 4/2, 2010.

Research

Research Vision: By understanding the underlying mechanisms of how cells and tissues work, we will be able to identify and develop new approaches for healthcare.
 

  • Mechanism of action of hormones and growth factors in chondrocytes and osteoblasts
  • Normal and pathological calcification
  • Tissue engineering
  • Response of cells to biomaterials

Research Center(s)