GENI Faculty Candidate Seminar: Mark S. Sundrud, PhD 2/15/22

Location: Hybrid Event- HSRB Auditorium/Zoom Streaming

Enterohepatic Immunology: New Perspectives on Intestinal Immune Regulation & Inflammation

Mark S. Sundrud, PhD
Department of Immunology & Microbiology
Scripps Research

Description: The two major forms of Inflammatory Bowel Disease (IBD), Crohn’s disease and ulcerative colitis, most commonly affect discrete regions of the intestinal tract – the small and large intestines, respectively. However, current immunological paradigms fail to distinguish between immune regulation in these two structurally and functionally distinct intestinal organs. In a series of recent studies from the lab, we have identified a novel pathway by which T cells in the small intestine lamina propria sense and respond to the presence of naturally circulating bile acids. This pathway emphasizes the unique features of T cells in the small, but not large, intestine; reveals dynamic and bi-directional crosstalk between small bowel inflammation and hepatic bile acid metabolism; and suggests safer and more selective approaches to target inflammation in patients with small bowel Crohn’s disease.

Click "RSVP" below to register by February 14th. After you register, a calendar invite (and Zoom link if applicable) will be sent to you.

Questions? Contact Gillian Glauber

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