The research focus of the Bunting lab is to understand the molecular mechanisms controlling hematopoietic and immune cell biology, including studies of hematopoietic stem cells, hematopoiesis, leukemogenesis, inflammation, and cancer. The main goal of our basic research is to generate innovative and translational therapeutic strategies for treating hematologic disorders.

Zhengqi Wang, PhD, Assistant Professor, Pediatric Hematology/Oncology

Yan Y, Dong L, Bunting KD, Stieglitz E, Loh ML, Qu CK. JMML tumor cells disrupt normal hematopoietic stem cells by imposing inflammatory stress through overproduction of IL-1β. Blood Adv., 2021005089.doi:10.1182. PMID: 3455855.

Wang Z, Mi T, Bradley HL, Metts J, Sabnis H, Zhu W, Arbiser J, Bunting KD. Pimozide and imipramine blue exploit mitochondrial vulnerabilities and reactive oxygen species to cooperatively target high risk acute myeloid leukemia. Antioxidants (Basel), 2021 Jun 15;10(6):956. doi: 10.3390/antiox10060956. PMCID: PMC8232307.

Wang Z, Vaughan TY, Zhu W, Chen Y, Fu G, Medryzcki M, Nishio H, Bunting ST, Hankey-Giblin P, Nusrat A, Parkos C, Wang D, Wen R, Bunting KD.  Gab2 and Gab3 redundantly suppress colitis by modulating macrophage and CD8+ T-cell activation. Front Immunol, doi: 10.3389/fimmu.2019.  PMCID:PMC6431666.

Lee JA, Wang Z, Sambo D, Bunting KD, Pallas DC. Global loss of leucine carboxyl methyltransferase-1 causes severe defects in fetal liver hematopoiesis. J Biol Chem, 293, 9636-9650, 2018. PMCID:PMC6016458.

Metts JL, Bradley HL, Wang Z, Kapur R, Shah N, Arbiser J, Bunting KD.  Imipramine blue sensitively and selectively targets FLT3-ITD positive AML cells. Scientific Reports, 7, 4447, doi:10.1038/s41598-017-04796-1, 2017. PMCID: PMC5493614.

Liu W, Yu WM, Zhang J, Chan RJ, Loh ML, Zhang Z, Bunting KD, Qu CK.  Inhibition of the Gab2/PI3K/mTOR signaling ameliorates myeloid malignancy caused by Ptpn11 (Shp2) gain-of-function mutations.  Leukemia, 31: 1415-1422, 2017. PMCID:PMC5462847.

Wang Z, Bunting KD.  Stat5 deficiency decreases transcriptional heterogeneity and supports emergence of hematopoietic sub-populations. Oncotarget, 8: 22477-22482, 2017.  PMCID:PMC5410237.


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