Overview

The research focus of the Bunting lab is to understand the molecular mechanisms controlling hematopoietic and immune cell biology, including studies of hematopoietic stem cells, hematopoiesis, leukemogenesis, inflammation, and cancer. The main goal of our basic research is to generate innovative and translational therapeutic strategies for treating hematologic disorders.

Zhengqi Wang, PhD, Assistant Professor, Pediatric Hematology/Oncology

Wang Z, Vaughan TY, Zhu W, Chen Y, Fu G, Medryzcki M, Nishio H, Bunting ST, Hankey-Giblin P, Nusrat A, Parkos C, Wang D, Wen R, Bunting KD.  Gab2 and Gab3 redundantly suppress colitis by modulating macrophage and CD8+ T-cell activation. Front Immunol, doi: 10.3389/fimmu.2019.  PMCID:PMC6431666 

Lee JA, Wang Z, Sambo D, Bunting KD, Pallas DC. Global loss of leucine carboxyl methyltransferase-1 causes severe defects in fetal liver hematopoiesis.  J Biol Chem, 293, 9636-9650, 2018. PMCID:PMC6016458 

Metts JL, Bradley HL, Wang Z, Kapur R, Shah N, Arbiser J, Bunting KD.  Imipramine blue sensitively and selectively targets FLT3-ITD positive AML cells.  Scientific Reports, 7, 4447, doi:10.1038/s41598-017-04796-1, 2017. PMCID: PMC5493614 

Liu W, Yu WM, Zhang J, Chan RJ, Loh ML, Zhang Z, Bunting KD, Qu CK.  Inhibition of the Gab2/PI3K/mTOR signaling ameliorates myeloid malignancy caused by Ptpn11 (Shp2) gain-of-function mutations.  Leukemia, 31: 1415-1422, 2017. PMCID:PMC5462847 

Wang Z, Bunting KD.  Stat5 deficiency decreases transcriptional heterogeneity and supports emergence of hematopoietic sub-populations. Oncotarget, 8: 22477-22482, 2017.  PMCID:PMC5410237 

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