Notice of Special Interest: Mechanisms Underlying the Contribution of Sleep Disturbances to Pain
Deadline: September 08, 2022
5 pm
Amount: Variable Amounts
Purpose
NICHD supports sleep and pain research as it relates to pediatric, neonatal, and adolescent, and young adult populations, pregnant women, and persons with intellectual or physical disabilities. NICHD specific areas of interest include the following:
Child Development and Behavior Branch interest areas include sleep and pain among normally developing children and adolescents, including non-pharmacologic interventions (e.g., cognitive, behavioral, psychologic) interventions for sleep and pain management, prevention of transition from acute to chronic pain, and mitigation of the acute pain experience. Possible research questions of interest include:
- What are the neurobiological pathways underlying sleep-pain relationships in pediatric populations?
- In sleep deficiency, what mechanisms (e.g., inflammation, pain sensitization, circadian misalignment) are involved in central pain modulatory pathways, and how do changes in pain processing relate to increased clinical pain vulnerability? How does long-term sleep deficiency affect analgesic mediators? Are same mechanisms involved at different developmental stages?
- Which sleep parameters are most predictive of longitudinal pain outcomes? When are most sensitive periods for development and intervention?
- What is the relationship between central circadian timing and pain? How can interventions that shift circadian timing modify pain?
- How do positive and negative affect mediate relationships between sleep impairment and pain outcomes in pediatric populations? How do positive affect and resilience buffer the potential effects of poor sleep on pain and functioning?
Submit applications for this initiative using one of the following FOAs or any reissues of these announcements through the expiration date of this Notice.
PA-19-056: Research Project Grant (Parent R01 Clinical Trial Not Allowed)
PA-18-480: NICHD Research Project Grant (R01 Clinical Trial Required)
PA-18-482: NICHD Exploratory/Developmental Research Grant (R21 - Clinical Trial Optional)
More Info: https://grants.nih.gov/grants/guide/notice-files/NOT-HD-19-020.html