Children’s Clinical and Translational Discovery Core

“The CTDC revolutionized our ability to conduct and lead the biologic correlates associated with both our single and multi-institutional clinical trials.  Because of our collaborations with the CTDC, the Aflac Cancer and Blood Disorders Center/Emory University is now able to serve as the coordinating center for two national clinical trials, and has developed a national reputation for being able to lead these type of research efforts.”

          - Thomas Cash, MD, Assistant Professor, Pediatric Hematology/Oncology

 

“The Emory University Children’s Clinical and Translational Discover Core is indispensable for our clinical and translational research.  The laboratory is very user-friendly and effective, which makes us feel confident handing our valuable samples to the CTDC.”

        - Larry Greenbaum, MD, Chief, Pediatric Nephrology


  • Clinical Trial Support:  Clinical sample processing and storage services for their subsequent use in hypothesis-driven clinical research.

  • Correlative Biology Studies: Support and advice on the conduct of correlative biology studies associated with clinical trials from initial study design and planning through the implementation and interpretation of molecular assays of drug targets and genomic correlates of disease.

  • Biorepository: Access to a variety of human biological specimens from both healthy control participants and patients with a variety of diagnoses.

The laboratory also collaborates with other core facilities and laboratories across campus.

For more information, email: CCTDC@emory.edu

Clinical sample processing and storage services for their subsequent use in hypothesis-driven clinical research.

  • Study Design Consulting
    • Complimentary 30 minute consultation to any interested investigator
    • If an investigator decides to use our services, they will be charged a $50 study startup/setup fee.
  • Sample Collection Kit Building
  • Biospecimen Processing
    • See Pricing tab
  • Biospecimen Storage
    • All specimens are tracked electronically via a Thermo Scientific Nautilus Laboratory Information Management System (LIMS). 
    • Samples are stored in secure laboratory spaces at 4˚C, -80˚C, and -150˚C. 
    • All storage equipment is monitored 24 hours a day/7 days a week by a Vaisala monitoring system. 
    • The CCTDC maintain back-up storage locations in case of individual equipment failure or widespread disaster.  
    • Clinical data for samples may be stored in a Research Electronic Data Capture (REDCap) system.
  • Sample Distribution

 

The CCTDC is also able to serve as the central repository for a multi-site study

Academic Biospecimen Processing Rates:

Kit based studies, or custom services, are billed according to time.  Investigators must consult Dr. Brad Hanberry to determine pricing.  Custom services utilizing core supplies will also be billed the market supply rate.  

  • Plasma = $18, per unit
  • Serum = $19, per unit
  • PBMC no revival + plasma aliquot = $32, per unit
  • PBMC revival + plasma aliquot = $33, per unit

 *Please contact Kristen Herzegh for industry rates.

Core Facilities are required to review rates on an annual basis and rates are subject to change.  Users with long-term projects should anticipate some increase in cost over the course of the study and budget accordingly.  

Subsidy Policy

Generous subsidies are offered to those users conducting pediatric focused investigator initiated studies.  Please contact Dr. Chris Porter to determine eligibility.  The maximum 2019 subsidy, per investigator, is $5,000. 

Support and advice on the conduct of clinical trials from initial study design and planning through the implementation and interpretation of molecular assays of drug targets and genomic correlates of disease.

Technical support and conduct of biologic assays in support of clinical trials.  This includes, but is not limited to:

  • Biological sample analysis
  • Cell culture assays
  • Western blotting
  • Quantitative real-time PCR
  • Custom Experimental Design

Access to a variety of human biological specimens from both healthy control participants and patients with a variety of diagnoses.

  • Emory University IRB approved Protocol, consent, and assent
  • On demand collection of biological samples
  • A growing repository of biological samples from both healthy control participants and patients with a variety of diagnoses
  • Oversight by the CCTDC Scientific Review Committee - This group provides oversight and guidance for all aspects of the Biorepository

Biospecimen Storage

  • All specimens are tracked electronically via a Thermo Scientific Nautilus Laboratory Information Management System (LIMS). 
  • Samples are stored in secure laboratory spaces at 4˚C, -80˚C, and -150˚C. 
  • All storage equipment is monitored 24 hours a day/7 days a week by a Vaisala monitoring system. 
  • The CCTDC maintain back-up storage locations in case of individual equipment failure or widespread disaster.  
  • Clinical data for samples may be stored in a Research Electronic Data Capture (REDCap) system.

 

If you are interested in requesting samples for research projects please fill out the Use Proposal Form and email it to CCTDC@emory.edu.

The Emory University Children’s Clinical and Translational Discovery Core (CTDC) is approved to collect 10-50mL of blood per participant.  The CTDC collects whole blood for processing into its components (plasma, serum, or PBMCs).  These processed samples are subsequently stored in the CTDC Biorepository for future distribution to approved investigators.  If an approved investigator requires fresh whole blood for their approved research project, then the following parameters will apply: 

-          If the requested volume of Whole Blood is <30mL then the CTDC, if needed/able, will collect up to 50mL of blood and distribute up to 30mL of the fresh whole blood to the investigator.  The remaining 20mL of blood will be processed and added to the CTDC Biorepository.  The participant will be compensated ($20 Target Gift Card) as indicated by the study protocol and consent.  The Principal Investigator will be billed for the time required to consent and draw the samples.   

-          If the requested volume of Whole Blood is > 30mL then the CTDC will only collect the volume requested by the investigator.  When a volume of blood > 30mL is requested, the CTDC will not have a sufficient volume of blood to process and store.  Participants will be compensated ($20 Target Gift Card) for their participation.  The Principal Investigator will be billed for the time required to consent and draw the samples, as well as supplies (including the participant $20 Target gift card).

Citing the Children’s Clinical and Translational Discovery Core 

The Children’s Clinical and Translational Discovery Core is generously supported by Children's Healthcare of Atlanta and Emory University.

When presenting or publishing work completed using the core, please include "Children's Healthcare of Atlanta and Emory University's Children’s Clinical and Translational Discovery Core" in the acknowledgments.

To determine if you should use “Children’s Healthcare of Atlanta” in your author affiliations, please see guidelines here.