• New Heart Gives Georgia Two-Year Old a Second Chance at Life

    October 02, 2017

    Two-year-old Kinsley Keeling lives like she's making up for lost time.  "Her enjoyment of life is so pure, and so exuberant, all the time," says Mary Beth Keeling, Kinsley's mother.  Keeling says it's almost as…

  • Engineering Research Center Will Help Expand Use of Therapies Based on Living Cells

    September 18, 2017

    The National Science Foundation (NSF) has awarded nearly $20 million to a consortium of universities to support a new engineering research center (ERC) that will work closely with industry and clinical partners to develop transformative tools and technologies for the consistent,…

  • “The prevalence and effects of aspiration among neonates at the time of discharge” Aylward & Mahle

    September 01, 2017

    Aspiration is common following neonatal cardiac surgery. The modified barium swallow study is often used to identify aspiration events and to determine an infant's risk for aspirating. This leads to a high proportion of infants who require tube feedings following neonatal cardiac surgery.

    Brandon Aylward, PhD & William Mahle, MD

  • Pilot Funding Report: Cardiac Fiber Imaging Using Ultrasound and DTI

    August 28, 2017

    Cardiac Fiber Imaging Using Ultrasound and DTI PI: Baowei Fei, Ph.D. 2014 HeRO Pilot Award   Cardiac fibers directly affect the mechanical, physiological and pathological properties of the heart. Heart failure (HF) is a leading cause of hospitalization, death,…

  • KO8 Awarded to Dr. Pam Winterberg

    August 24, 2017

    Chronic kidney disease (CKD) causes early death from a type of heart failure due to a thick and stiff heart. Our project is trying to better understand what causes the thick and stiff heart during CKD and to find new…

  • Xu Lab Published in Stem Cell Reports

    August 22, 2017

    Downregulation of LGR5 Expression Inhibits Cardiomyocyte Differentiation and Potentiates Endothelial Differentiation from Human Pluripotent Stem Cells Rajneesh Jha, Monalisa Singh, Qingling Wu, Cinsley Gentillon, Marcela K. Preininger, Chunhui Xu Understanding molecules involved in…

  • R21 Awarded to Dr. Erin Buckley

    July 21, 2017

    In July, Dr. Buckley received an R21 from the NIH/NHLBI through their “Bold New Bioengineering Methods and Approaches for Heart, Lung, Blood, and Sleep Disorders and Diseases” funding opportunity.  Her proposal, entitled “Microvascular cerebral blood…

  • Dr. Park Awarded RO1 “Mechanisms of ER71/ETV2-Regulated Vascularization”

    July 14, 2017

    The transcription factor ER71 (also known as ETV2) is a critical regulator of FLK1 whose function is essential for vessel development and post-natal angiogenesis. The overall goal of this proposal is to investigate mechanisms by which ER71 regulates Flk1 expression and neovascularization by employing mouse genetic models and mouse embryonic stem cell differentiation system. Our preliminary studies provide compelling evidence showing its potent and unexpected functions in the mechanism of vascular endothelial cell generation and revascularization in the adult, and thus outcome from this application will provide a new research platform which could lead to the development of new therapeutic strategies for cardiovascular diseases.