Clinical & Translational Core
The goal of the CF@LANTA RDP Center is to promote interdisciplinary research into the pathogenesis of CF and translate this new knowledge into therapeutic strategies to improve longevity and quality of life for people with CF. Our strategy to reach this goal centers upon the ~660 CF patients cared for within our clinical program and the Clinical and Translation Core (CTC) is a mechanism for achieving this strategy. Furthermore, the RDP builds upon our CF clinical and translational research experience over the last five years focused on two extraordinarily important clinical co-morbidities in CF-acute pulmonary exacerbations (APEs) and CF-Related Diabetes (CFRD). Thus, the goal of the CTC is to provide guidance and expertise in the successful conduct of CF human research focused on APEs and CFRD. Arlene Stecenko, MD serves as core direct for the CTC. The CTC includes the previously established CF Discovery Core and has these goals:
The CF Biospecimen Registry (CF-BR) is the cornerstone of the CTC. This unit couples the CF Foundation supported clinical database of patients followed at our CF Care Center with a biospecimen repository of blood, sputum, exhaled breath condensate (EBC), nasal scrapings, throat swabs, patient bacterial isolates, and bronchoalveolar fluid (BALF). The CF-BR provides these samples and the associated clinical data to CF investigators via the CF Discovery Core.
Faculty in this Core provide scientific, intellectual, and clinical consultation to CF@LANTA RDP Center investigators. Specifically, the CTC assists investigators in preparation of research proposals, training of their research staff, and understanding the data and specimens available to them through the CF-BR. Faculty also have oversight of CTC research coordinators who collect samples and distribute or store them as appropriate. The CTC maintains Standard Operating Procedures (SOPs) for collection of sputum (induced and expectorated), blood, EBC, BALF, and nasal scrapings as well as transportation of the samples from the clinic/hospital to the appropriate cores or individual labs in order to optimize stability and validity of the sample. Thus, all specimen collection and handling are standardized across all research protocols.
Faculty in the CTC provide statistical consultation for experimental design of clinical and translational research projects, power/sample size calculations, data analysis, and development of grant proposals and manuscripts. The CTC also provides data management that provides a seamless interface between the type of specimens collected, the clinical data in the CFF Registry, and the biostatistical support team.