Neonatology Research

The division of neonatology is actively engaged in basic, clinical and translational research, including participation in the NICHD Neonatal Research Network and the Children's Hospital Neonatal Consortium. Our division is also active in efforts to translate available evidence to clinical practice through local quality improvement efforts and collaborative initiatives within the Children's Hospital Neonatal Consortium, Vermont Oxford Network and Georgia Perinatal Quality Collaborative

2018

Jain L. Unfinished Business: Prematurity, Birth Asphyxia, and Stillbirths. Clin Perinatol. 2018 Jun;45(2):xv-xviii.

Patel RM, Manuck TA. Collaboratively Understanding and Improving Outcomes for the Mother, Fetus, and Infant. Clin Perinatol. 2018 Jun;45(2):xix-xx.

Pakvasa MA, Saroha V, Patel RM. Optimizing Caffeine Use and Risk of Bronchopulmonary Dysplasia in Preterm Infants: A Systematic Review, Meta-analysis, and Application of GRADE Methodology. Clin Perinatol. 2018 Jun;45(2):273-291.

Schlager A, Arps K, Siddharthan R, Glenn I, Hill SJ, Wulkan ML, Keene SD, Clifton MS. Thoracoscopic Repair of Congenital Diaphragmatic Hernia After Extracorporeal Membrane Oxygenation: Feasibility and Outcomes. J Laparoendosc Adv Surg Tech A. 2018 Mar 12.

Adams-Chapman I, Heyne RJ, DeMauro SB, Duncan AF, Hintz SR, Pappas A, Vohr BR, McDonald SA, Das A, Newman JE, Higgins RD; Follow-Up Study of the Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network. Neurodevelopmental Impairment Among Extremely Preterm Infants in the Neonatal Research Network. Pediatrics. 2018 May;141(5).

Grunwell JR, Yeligar SM, Stephenson S, Ping XD, Gauthier TW, Fitzpatrick AM, Brown LAS. TGF-β1 Suppresses the Type I IFN Response and Induces Mitochondrial Dysfunction in Alveolar Macrophages. J Immunol. 2018 Mar 15;200(6):2115-2128.

Jain L. Hormonal Regulation of Human Development. Clin Perinatol. 2018 Mar;45(1):xiii-xv.

Karpen HE. Mineral Homeostasis and Effects on Bone Mineralization in the Preterm Neonate. Clin Perinatol. 2018 Mar;45(1):129-141.

Kane AF, Bhatia AD, Denning PW, Shane AL, Patel RM. Routine Supplementation of Lactobacillus rhamnosus GG and Risk of Necrotizing Enterocolitis in Very Low Birth Weight Infants. J Pediatr. 2018 Apr;195:73-79.e2.

Han JE, Alvarez JA, Staitieh B, Tangpricha V, Hao L, Ziegler TR, Martin GS, Brown LAS. Oxidative stress in critically ill ventilated adults: effects of vitamin D(3) and associations with alveolar macrophage function. Eur J Clin Nutr. 2018 May;72(5):744-751.

Maheshwari A, Patel RM, Christensen RD. Anemia, red blood cell transfusions, and necrotizing enterocolitis. Semin Pediatr Surg. 2018 Feb;27(1):47-51.

Patel RM, Underwood MA. Probiotics and necrotizing enterocolitis. Semin Pediatr Surg. 2018 Feb;27(1):39-46.

Pappas A, Adams-Chapman I, Shankaran S, McDonald SA, Stoll BJ, Laptook AR, Carlo WA, Van Meurs KP, Hintz SR, Carlson MD, Brumbaugh JE, Walsh MC, Wyckoff MH, Das A, Higgins RD; Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network. Neurodevelopmental and Behavioral Outcomes in Extremely Premature Neonates With Ventriculomegaly in the Absence of Periventricular-Intraventricular Hemorrhage. JAMA Pediatr. 2018 Jan 1;172(1):32-42.

 

2017

Bhatt D, Travers C, Patel RM, Shinnick J, Arps K, Keene S, Raval MV. Predicting Mortality or Intestinal Failure in Infants with Surgical Necrotizing Enterocolitis. J Pediatr. 2017 Dec;191:22-27.e3.

Vyas-Read S, Vance RJ, Wang W, Colvocoresses-Dodds J, Brown LA, Koval M. Hyperoxia induces paracellular leak and alters claudin expression by neonatal alveolar epithelial cells. Pediatr Pulmonol. 2018 Jan;53(1):17-27.

Jain L. Minimally Invasive Surgery: Is It the Carpenter or the Tools? Clin Perinatol. 2017 Dec;44(4):xv-xvii.

Laptook AR, Shankaran S, Tyson JE, Munoz B, Bell EF, Goldberg RN, Parikh NA, Ambalavanan N, Pedroza C, Pappas A, Das A, Chaudhary AS, Ehrenkranz RA, Hensman AM, Van Meurs KP, Chalak LF, Khan AM, Hamrick SEG, Sokol GM, Walsh MC, Poindexter BB, Faix RG, Watterberg KL, Frantz ID 3rd, Guillet R, Devaskar U, Truog WE, Chock VY, Wyckoff MH, McGowan EC, Carlton DP, Harmon HM, Brumbaugh JE, Cotten CM,Sánchez PJ, Hibbs AM, Higgins RD; Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network. Effect of Therapeutic Hypothermia Initiated After 6 Hours of Age on Death or Disability Among Newborns With Hypoxic-Ischemic Encephalopathy: A Randomized Clinical Trial. JAMA. 2017 Oct 24;318(16):1550-1560..

Patel RM, Zimmerman K, Carlton DP, Clark R, Benjamin DK, Smith PB. Early Caffeine Prophylaxis and Risk of Failure of Initial Continuous Positive Airway Pressure in Very Low Birth Weight Infants. J Pediatr. 2017 Nov;190:108-111.e1.

Jain L. Quality Improvement: The Journey Continues! Clin Perinatol. 2017 Sep;44(3):xv-xvi.

Roberts JL, Patel RM. Antibiotic utilisation in very low birth weight infants without sepsis or necrotising enterocolitis is associated with multiple adverse outcomes. Evid Based Med. 2017 Oct;22(5):187.

Vyas-Read S, Kanaan U, Shankar P, Stremming J, Travers C, Carlton DP, Fitzpatrick A. Early characteristics of infants with pulmonary hypertension in a referral neonatal intensive care unit. BMC Pediatr. 2017 Jul 11;17(1):163.

Patel RM, Rysavy MA, Bell EF, Tyson JE. Survival of Infants Born at Periviable Gestational Ages. Clin Perinatol. 2017 Jun;44(2):287-303.

Jain L. Confronting the Limits of Viability. Clin Perinatol. 2017 Jun;44(2):xv-xvii.

Pallotto EK, Piazza AJ, Smith JR, Grover TR, Chuo J, Provost L, Mingrone T, Holston M, Moran S; DNP, Morelli L; LNCC, Zaniletti I, Brozanski B. Sustaining SLUG Bug CLABSI Reduction: Does Sterile Tubing Change Technique Really Work? Pediatrics. 2017 Oct;140(4). pii: e20163178.

Di Fiore JM, Martin RJ, Li H, Morris N, Carlo WA, Finer N, Walsh M; SUPPORT Study Group of the Eunice Kennedy Shriver National Institute of Child Health, and Human Development Neonatal Research Network. Patterns of Oxygenation, Mortality, and Growth Status in the Surfactant Positive Pressure and Oxygen Trial Cohort. J Pediatr. 2017 Jul;186:49-56.e1.

Gauthier TW, Grunwell JR, Ping XD, Harris FL, Brown LA. Impaired defenses of neonatal mouse alveolar macrophage with cftr deletion are modulated by glutathione and TGFβ1. Physiol Rep. 2017 Mar;5(6). pii: e13086.

Younge N, Goldstein RF, Bann CM, Hintz SR, Patel RM, Smith PB, Bell EF, Rysavy MA, Duncan AF, Vohr BR, Das A, Goldberg RN, Higgins RD, Cotten CM; Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network. Survival and Neurodevelopmental Outcomes among Periviable Infants. N Engl J Med. 2017 Feb 16;376(7):617-628.

Engle WA, West KW, Hocutt GA, Pallotto EK, Haney B, Keith RJ, Stewart DL, Knodel E, Suttner D, Chapman R, Thomas A, Schwerin B, Stork E, Crowley M, Piazza AJ, Heard ML, Gebregziabher N, Fadel W, Bartlett R. Adult Outcomes After Newborn Respiratory Failure Treated With Extracorporeal Membrane Oxygenation. Pediatr Crit Care Med. 2017 Jan;18(1):73-79.

James J, Munson D, DeMauro SB, Langer JC, Dworetz AR, Natarajan G, Bidegain M, Fortney CA, Seabrook R, Vohr BR, Tyson JE, Bell EF, Poindexter BB, Shankaran S, Higgins RD, Das A, Stoll BJ, Kirpalani H; Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network. Outcomes of Preterm Infants following Discussions about Withdrawal or Withholding of Life Support. J Pediatr. 2017 Nov;190:118-123.e4.

Shankaran S, Laptook AR, Pappas A, McDonald SA, Das A, Tyson JE, Poindexter BB, Schibler K, Bell EF, Heyne RJ, Pedroza C, Bara R, Van Meurs KP, Huitema CMP, Grisby C, Devaskar U, Ehrenkranz RA, Harmon HM, Chalak LF, DeMauro SB, Garg M, Hartley-McAndrew ME, Khan AM, Walsh MC, Ambalavanan N, Brumbaugh JE, Watterberg KL, Shepherd EG, Hamrick SEG, Barks J, Cotten CM, Kilbride HW, Higgins RD; Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network. Effect of Depth and Duration of Cooling on Death or Disability at Age 18 Months Among Neonates With Hypoxic-Ischemic Encephalopathy: A Randomized Clinical Trial. JAMA. 2017 Jul 4;318(1):57-67.

These are selected areas of research focus within the division and associated investigators (please see first table for investigator details):

  • Oxidant stress markers in exhaled breath condensate and tracheal aspirates (Gauthier)
  • Biomarkers of in utero ethanol exposure (Gauthier)
  • Necrotizing enterocolitis (Denning, Patel, Piazza, Hamrick, Adams-Chapman)
  • Severe bronchopulmonary dysplasia and associated pulmonary hypertension (Vyas-Read)
  • Human milk feeding in neonates with congenital gastrointestinal disorders (Karpen)
  • Redox states and arginine insufficiency in preterm infants (Brown)
  • Neuroimaging and long-term outcomes (Hamrick, Adams-Chapman)
  • Congenital diaphragmatic hernia and ECMO (Keene)

In addition, multiple faculty members are invovled in studies with the:

  • NICHD Neonatal Research Network
  • Children's Hospital Neonatal Database

Yvonne Loggins, RN, BSN

Diane Bottcher, RN, MN

Colleen Mackie, RT

Beatrice Shelly Connor, CRN II