Larry J Anderson, MD
Division of Infectious Disease
Department of Pediatrics
Emory University School of Medicine
Larry Anderson came to Emory from the Centers for Disease Control and Prevention.
His research program focuses on the immunopathogensis of respiratory viral infections, especially respiratory syncytial virus (RSV). Larry also assists Paul Spearman in running the Division of Infectious Diseases and helps other staff develop their research programs. His research programs focus on understanding viral contributors to RSV disease pathogenesis especially that associated with the RSV G protein. This protein has a chemokine motif that modulates the host response to infection and likely is an important contributor to pathogenesis of disease. Larry's work at CDC in animal model systems suggested that binding this region of the G protein with a MAb will both neutralize the virus and decrease the virus-induced host immune response that likely contributes to severity of disease.
This work provided the foundation for recently initiated clinical studies of a human monoclonal antibody for treatment and prevention of RSV disease. Dr. Anderson, with collaborators at CDC, University of Georgia and Emory, are now exploring how understanding the role that this chemokine motif and other viral proteins play in RSV disease can help in the design of a safe and effective vaccine. He is also developing collaborative studies to apply pathogen discovery tools to diseases of unknown etiology and understand the role of respiratory virus infections in asthma.