Stephen P Diggle, PhD
School of Biological Sciences
My group is interested in the evolution of bacterial signalling and communication (quorum sensing), cooperation and conflict in populations, and the implications for the evolution of virulence and antibiotic resistance during infection. Our emphasis is on chronic infections such as those found in cystic fibrosis lungs and in non-healing wounds and diabetic ulcers. We have recently shown that phenotypic and genotypic diversity in Pseudomonas aeruginosa cystic fibrosis infections is driven by recombination and that this has implications for antibiotic resistance and susceptibility testing. We have also pioneered an ex vivo pig lung model for studying bacterial virulence and biofilm formation in lung tissue and bronchioles. This allows researchers to study individual bacterial species and multi-species populations in a chemically and structurally relevant environment.