John "Pete" Lollar, III, MD
Research Director, Hemostasis
Children’s Healthcare of Atlanta
Division of Hematology/Oncology - Hematology
Department of Pediatrics
Emory University School of Medicine
Dr. Lollar is Director of Hemostasis Research in the Aflac Cancer and Blood Disorders Center, Professor of Pediatrics, and Hemophilia of Georgia, Inc., Chair in Hemostasis. He has directed a research team for over 25 years with the goals of obtaining a better understanding of basic mechanisms of hemostasis and improving treatment for patients with hemophilia, and is currently funded by 2 NIH R01s. Inhibitory antibodies to factor VIII, the protein that is missing in hemophilia, lead to serious bleeding problems in patients with hemophilia. Dr. Lollar’s group is characterizing the regions of the factor VIII molecule to which these inhibitors bind. They have developed a recombinant porcine factor VIII product with reduced antigenicity with respect to inhibitors that is in phase 3 clinical testing. Additionally, Dr. Lollar’s group is pursuing methods to increase the synthesis of factor VIII, which may be applicable to the problem of developing gene therapy for patients with hemophilia A.