Joshua D. Chandler, PhD
Assistant Professor of Pediatrics
Pulmonology, Allergy/Immunology, CF, & Sleep
My research focuses on the diverging roles of oxidants generated during airway inflammation, particularly from neutrophils, and how shifts in the abundance of one oxidant at the expense of others drive changes in biological and health outcomes (such as altered epithelial cell signaling and improved patient lung function). I call this approach, which is complementary to but different from antioxidant intervention, “oxidant switching”. Using clinical, animal, cellular and biochemical methods, I seek to identify redox-selective targets to promote resolution of inflammation and healthy lung tissue behavior. My major disease focus is cystic fibrosis (CF), in which excessive neutrophils in the airways heavily contribute to disease progression. However, I believe my research will also benefit patients with other inflammatory lung diseases, such as COPD and asthma, by identifying and targeting central redox-mediated pathways of resolving inflammation through oxidant switching.
BA, Biology and Chemistry, Drury University, 2009
PhD, Molecular Toxicology, University of Colorado, 2014; PI: Brian J. Day, PhD
Postdoctoral Fellowship, Emory University, 2014-2017; PIs: Dean P. Jones, PhD and Young-Mi Go, PhD