James Dahlman, PhD
Department of Biomedical Engineering
313 Ferst Drive
Atlanta, GA, 30313
I am an Assistant Professor in the Georgia Tech BME Department. My lab works at the interface of chemical engineering, nanotechnology, genomics, and gene editing. We design nanotechnology for targeted drug delivery. We have designed nanoparticles that deliver RNAs to the lung and heart. These nanoparticles have been used by over ten labs across the US, and are under consideration for clinical trials. We also use nanotechnology for in vivo combination therapies; nanoparticles deliver multiple therapeutic RNAs at once, in order to manipulate several different genes on a single disease pathway. More recently, we developed a method to quantify the targeting and biodistribution of dozens (or hundreds) of distinct nanoparticles at once. We will use this new technology to (a) deliver nucleic acids to new cell types, and (b) study how the chemical structure of nanoparticles affects their behavior in animals. Finally, we use molecular biology to design the gene editing drugs we want to deliver. We recently reported ‘dead’ guide RNAs; these engineered RNAs can simultaneously up- and down-regulate gene combinations in a single cell using CRISPR-Cas9.