Faculty Directory

Daniel S. Wechsler, MD, PhD

Daniel S. Wechsler, MD, PhD headshot

Professor of Pediatrics
Section Director of Pediatric Oncology
Thomas R. Giddens Chair
Aflac Cancer and Blood Disorders Center
Children’s Healthcare of Atlanta/Emory University

EMAIL: .(JavaScript must be enabled to view this email address)
PHONE: 404-727-3620

Biography

Our research focuses on the pathogenesis of infant leukemias. We have shown that the nuclear export chaperone CRM1 plays a direct role in CALM-AF10 leukemogenesis by activating HOXA gene expression. CRM1 appears to be similarly involved in other leukemias, suggesting that available CRM1 inhibitors may be effective anti-leukemic therapeutic agents.
 

Research

Molecular Biology of Neuroblastoma
Regulation of Transcription of MYC family proteins
Role of Endocytosis in Pathogenesis of Acute Myeloid Leukemia
Pathogenesis of MLL-dependent Acute Leukemia
Nuclear Export Signals in Leukemogenesis

Primary Center