Bringing In The Research Dollars! (BiRD)

Improvement of Animal Models for Stem Cell-Based Regenerative Medicine (R24)—upcoming deadline

Deadline: January 25, 2019

Amount: Application budgets are not limited but need to reflect the actual needs of the proposed project. Maximum award period is 4 years.


Encourages research aimed at characterizing animal stem cells and improving existing, and creating new, animal models for human disease conditions.  The intent of this initiative is to facilitate the use of stem cell-based therapies for regenerative medicine. The initiative focuses on the following areas: 1) comparative analysis of animal and human stem cells to provide information for selection of the most predictive and informative model systems; 2) development of new technologies for stem cell characterization and transplantation; and 3) improvement of animal disease models for stem cell-based therapeutic applications.   Development of an animal-based resource often requires preliminary work that is research-based. This resource-related research is often not hypothesis driven and cannot be addressed appropriately by NIH R01 or R21 grant applications. Accordingly, ORIP/DPCPSI supports resource grants which have the following features:

  • The grants support applied studies to characterize and develop new animal based resources or to improve existing resources.
  • The grants support research projects that contribute to the knowledge of a model system, making the system more useful and accessible to the research community.
  • In all cases, the potential results of investigations must be applicable to the research interests of two or more of categorical NIH Institutes and Centers (ICs). Furthermore, investigations of a disease or category of research that predominantly relates to the interests of one NIH categorical IC and peripherally relates to the interests of other NIH ICs are not appropriate for this FOA. Preference will be given to investigations that examine general principles involved in developing the most informative animal models for regenerative medicine, rather than focusing on a specific disease.  However, investigations involving specific diseases can be used as proof of principle.  An example of an inappropriate request is one exclusively involving an animal model of cancer, heart disease, or neurological disorders. The ultimate objective of these efforts should be to provide essential preclinical knowledge that can help inform future clinical investigations.
  • The particular emphasis of a specific application can vary in regard to the balance of research- versus resource-related activities, depending on the state of the art at the time.  An application can be predominantly research based, if the research will plausibly lead to development of a resource, or can be predominantly aimed at final development or enhancement of a resource if most of the necessary research has already been accomplished.
  • The application must demonstrate a need for the resource (or resource to be developed) by the biomedical research community.
  • Cost recovery is not required.


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